职称：副研究员，深圳市高层次人才，深圳中山妇产医院检验中心主任

　　研究方向：生殖免疫

　　擅长领域： 子宫内膜生理及病理炎症状态(慢性子宫内膜炎)对不孕患者妊娠结局的影响及病理机制

　　学术任职：中国免疫学会生殖免疫分会第五届委员会委员、广东省免疫学生殖免疫学专业委员会常务委员、深圳市医院协会检验医学分会常务委员

　　学术成果：

　　一、主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序)：

　　1、 深圳市自然科学基金、JCYJ20190803142103857、早孕期滋养细胞通过IDO-AhR诱导蜕膜CD8+T细胞PD-1表达的机制研究、2020/08-2023/08，10万，在研，主持。

　　2、 国家自然科学基金青年项目、81601279、子宫内膜CD8+T细胞通过Fas通路促进滋养细胞侵袭的分子机制研究，2017/01-2019/12，17.5万，主持，结题。

　　3、中华医学会临床医学科研专项资金、16020200636、子宫内膜CD8+T细胞对滋养层细胞调控机制的研究，2017/01-201912，11万，主持，结题。

　　二、代表性研究成果和学术奖励(分类按时间倒序排序)：

　　1) Cong Chen#, Chunyu Huang, Yaya Wu, Zhihong, Li, Shuyi Yu, Ruochun Lian, Rong Lin, Lianghui Diao, Yong Zeng, Yuye Li*. Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis. J. Vis. Exp. (200), e65643, doi:10.3791/65643 (2023).

　　2) Hongzhan Zhang#, Han Qiu#, Zhiqiang Liu, Shuyi Yu，Cong Chen, Yong Zeng, Yuye Li*.The endometrial preparation protocol had no impact on pregnancy outcomes in frozen embryo transfer cycles of patients with cured chronic endometritis. RBMO, November 27, 2023.

　　3) Shuyi Yu#,Lianghui Diao, Ruochun Lian, Cong Chen, Chunyu Huang, Xinyuan Li, Yuye Li*, Yong Zeng*. Comparing the peri-implantation endometrial T-bet/GATA3 ratio between control fertile women and patients with recurrent miscarriage: establishment and application of a reference range. Human Reproduction. 2023; 38(9):1680-1689.

　　4) Shuyi Yu#, Ruochun Lian, Cong Chen, Xian Chen, Jian Xu, Yong Zeng*, Yuye Li*. Impact of body mass index on peripheral and uterine immune status in the window of implantation in patients with recurrent reproductive failure. 2023;26(5):1322-1333.

　　5) Shuyi Yu#, Chunyu Huang, Ruochun Lian, Lianghui Diao, Xueling Zhang, Song-chen Cai,Hongxia Wei, Cong Chen, Yuye Li*, Yong Zeng*. Establishment of reference intervals of endometrial immune cells during the mid-luteal phase. J Reprod Immunol. 2023;156:103822.

　　6) Yuye Li#, Yanhong Xu#, Shuyi Yu, Shenglai Lin, Wanru Chen, Ruochun Lian, Lianghui Diao, Haixiang Sun, Lijun Ding*, Yong Zeng*. Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study. Taiwan J Obstet Gynecol. 2022;61:984-988.

　　7) Yuye Li#, Shuyi Yu#, Chunyu Huang, Lianghui Diao, Cong Chen, Wenjuan Liu, Ruochun Lian, Meilan Mo, Chenyang Du, Fenghua Liu*, Yong Zeng*. Predictive role of endometrial T-bet/GATA3 ratio during mid-luteal phase for live birth in patients undergoing in vitro fertilization: A retrospective observational study. J Reprod Immunol. 2022;149:103465.

　　8) Yuye Li#, Shiru Xu#, Shuyi Yu, Chunyu Huang, Shenglai Lin, Wanru Chen, Meilan Mo, Ruochun Lian, Lianghui Diao, Lijun Ding*, Yong Zeng*. Diagnosis of chronic endometritis: How many CD138+ cells/HPF in endometrial stroma affect pregnancy outcome of infertile women? Am J Reprod Immunol. 2021;85:e13369.

　　9) Yuye Li#, Shuyi Yu#, Chunyu Huang, Ruochun Lian, Cong Chen, Su Liu, Longfei Li, Lianghui Diao, Udo R. Markert*, Yong Zeng*. Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure. Fertil Steril. 2020;113:187-196 e181.

　　10) Biao Yin#, Yong Zeng, Tonghua Wu, Shuyi Yu, Jian Xu, Su Liu, Lianghui Diao, Zhenfu Zhao, Desheng Liang*, Yuye Li*. Functional properties of peripheral CD8+ T cells in patients with repeated implantation failure. Am J Reprod Immunol. 2017;78.

　　专利

　　1) 黄春宇，刁梁辉，陈现，李玉叶，连若纯，陈聪，一种评估子宫内膜容受性的试剂盒，2017-10-31，中国，ZL201610021908.X.

　　2) 李玉叶，余姝毅，黄春宇，连若纯，刁梁辉，杜晨阳，陈聪，黎心缘，曾勇，一种用于预测不孕症患者的妊娠结局的生物标志物及其应用，2020-07-29，中国，ZL2-2-1-744091.5.

　　科技奖励

　　不明原因复发性流产免疫状态评估体系的建立，深圳市，深圳市科学技术进步奖，一等奖，2016.(9/14)